Journal
BIOMEDICAL OPTICS EXPRESS
Volume 4, Issue 11, Pages 2570-2584Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.4.002570
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Funding
- IOP Photonic Devices program
- Technology Foundation STW and AgentschapNL [IPD12020]
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Spectroscopic optical coherence tomography (sOCT) enables the mapping of chromophore concentrations and image contrast enhancement in tissue. Acquisition of depth resolved spectra by sOCT requires analysis methods with optimal spectral/spatial resolution and spectral recovery. In this article, we quantitatively compare the available methods, i.e. the short time Fourier transform (STFT), wavelet transforms, the Wigner-Ville distribution and the dual window method through simulations in tissue-like media. We conclude that all methods suffer from the trade-off in spectral/spatial resolution, and that the STFT is the optimal method for the specific application of the localized quantification of hemoglobin concentration and oxygen saturation. (C) 2013 Optical Society of America
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