Journal
BIOMEDICAL OPTICS EXPRESS
Volume 4, Issue 12, Pages 2828-2834Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.4.002828
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Funding
- National Institutes of Health [NIH CA-114542]
- National Pancreas Foundation
- Wallace H. Coulter Foundation
- U of M Comprehensive Cancer Center
- U of M Medical School Translational Research Program
- American Society for Gastrointestinal Endoscopy
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In a pilot study, multimodal optical spectroscopy coupled with quantitative tissue-optics models distinguished intraductal papillary mucinous neoplasm (IPMN), a common precursor to pancreatic cancer, from normal tissues in freshly excised human pancreas. A photon-tissue interaction (PTI) model extracted parameters associated with cellular nuclear size and refractive index (from reflectance spectra) and extracellular collagen content (from fluorescence spectra). The results suggest that tissue optical spectroscopy has the potential to characterize pre-cancerous neoplasms in human pancreatic tissues. (C) 2013 Optical Society of America
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