Journal
BIOMEDICAL OPTICS EXPRESS
Volume 4, Issue 11, Pages 2596-2608Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.4.002596
Keywords
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Funding
- NIH [R01-EY013178, R01-EY011289, R44-EY018986, P30-EY008098]
- Eye and Ear Foundation (Pittsburgh, PA)
- Research to Prevent Blindness (New York, NY)
- German Research Foundation [DFG-HO-1791/11-1]
- Erlangen Graduate School in Advanced Optical Technologies (SAOT) [DFG-GSC80-SAOT]
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We demonstrate an automated segmentation method for in-vivo 3D optical coherence tomography (OCT) imaging of the lamina cribrosa (LC). Manual segmentations of coronal slices of the LC were used as a gold standard in parameter selection and evaluation of the automated technique. The method was validated using two prototype OCT devices; each had a subject cohort including both healthy and glaucomatous eyes. Automated segmentation of in-vivo 3D LC OCT microstructure performed comparably to manual segmentation and is useful for investigative research and in clinical quantification of the LC. (C) 2013 Optical Society of America
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