Journal
BIOMEDICAL OPTICS EXPRESS
Volume 4, Issue 8, Pages 1413-1421Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.4.001413
Keywords
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Funding
- Ministry of Health, Welfare & Family Affairs, Republic of Korea [A101954]
- National Research Foundation of Korea (NRF)
- Korea government (MEST) [2009-0093432, 2011-0013169, 2012R1A2A2A01047402, 2012R1A1B3001831]
- National Research Foundation of Korea [2012R1A2A2A01047402, 2011-0013169, 2009-0093432, 2012R1A1B3001831] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The feasibility of terahertz (THz) imaging at frozen temperature for the clinical application of oral cancer detection was investigated by analyzing seven oral tissues resected from four patients. The size, shape, and internal position of the oral cancers were mapped by THz radiation in the frequency range of 0.2-1.2 THz at -20 degrees C and 20 degrees C, and compared with those identified in the histological examination. THz imaging of frozen tissue was found to offer greater sensitivity in distinguishing cancerous areas from surrounding tissue and a larger THz-frequency spectral difference between the oral cancer and normal mucosa than roomtemperature THz imaging. A cancerous tumor hidden inside tissue was also detected using this method by observing the THz temporal domain waveform. The histological analysis showed that these findings resulted from cell structure deformations involving the invasion of oral tumor and neoplastic transformations of mucous cells. Therefore, a cytological approach using THz radiation at a frozen temperature might be applied to detect oral cancer. (C) 2013 Optical Society of America
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