Journal
BIOMEDICAL OPTICS EXPRESS
Volume 3, Issue 12, Pages 3138-3152Publisher
Optica Publishing Group
DOI: 10.1364/BOE.3.003138
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Funding
- Raine Medical Research Foundation
- UWA Gledden Visiting Senior Fellowship
- European Heads of Research Councils (EuroHORCs)
- European Science Foundation [ESF-EURYI 01/2007PL]
- Polish Ministry of Science and Higher Education
- Scholarship for International Research Fees and University International Stipend, UWA
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Optical coherence elastography employs optical coherence tomography (OCT) to measure the displacement of tissues under load and, thus, maps the resulting strain into an image, known as an elastogram. We present a new improved method to measure vibration amplitude in dynamic optical coherence elastography. The tissue vibration amplitude caused by sinusoidal loading is measured from the spread of the Doppler spectrum, which is extracted using joint spectral and time domain signal processing. At low OCT signal-to-noise ratio (SNR), the method provides more accurate vibration amplitude measurements than the currently used phase-sensitive method. For measurements performed on a mirror at OCT SNR = 5 dB, our method introduces <3% error, compared to >20% using the phase-sensitive method. We present elastograms of a tissue-mimicking phantom and excised porcine tissue that demonstrate improvements, including a 50% increase in the depth range of reliable vibration amplitude measurement. (C) 2012 Optical Society of America
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