Journal
BIOMEDICAL OPTICS EXPRESS
Volume 3, Issue 2, Pages 366-379Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.3.000366
Keywords
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Funding
- William & Marlene Schrader Postgraduate Scholarship
- Cancer Council Western Australia
- National Breast Cancer Foundation, Australia
- National Breast Cancer Foundation [NC-12-19] Funding Source: researchfish
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We report the use of optical coherence tomography (OCT) to determine spatially localized optical attenuation coefficients of human axillary lymph nodes and their use to generate parametric images of lymphoid tissue. 3D-OCT images were obtained from excised lymph nodes and optical attenuation coefficients were extracted assuming a single scattering model of OCT. We present the measured attenuation coefficients for several tissue regions in benign and reactive lymph nodes, as identified by histopathology. We show parametric images of the measured attenuation coefficients as well as segmented images of tissue type based on thresholding of the attenuation coefficient values. Comparison to histology demonstrates the enhancement of contrast in parametric images relative to OCT images. This enhancement is a step towards the use of OCT for in situ assessment of lymph nodes. (C) 2012 Optical Society of America
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