Journal
BIOMEDICAL OPTICS EXPRESS
Volume 3, Issue 9, Pages 1978-1992Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.3.001978
Keywords
-
Funding
- Cystic Fibrosis Foundation CFFT [BUTTON07XX0]
- NIH [1R01HL092964, 2R01HL07546]
- NFS [DMS 1100281]
- Cystic Fibrosis Foundation [HILL0810]
- startup funds from UNC Chapel Hill (Oldenburg)
Ask authors/readers for more resources
Muco-ciliary transport in the human airway is a crucial defense mechanism for removing inhaled pathogens. Optical coherence tomography (OCT) is well-suited to monitor functional dynamics of cilia and mucus on the airway epithelium. Here we demonstrate several OCT-based methods upon an actively transporting in vitro bronchial epithelial model and ex vivo mouse trachea. We show quantitative flow imaging of optically turbid mucus, semi-quantitative analysis of the ciliary beat frequency, and functional imaging of the periciliary layer. These may translate to clinical methods for endoscopic monitoring of muco-ciliary transport in diseases such as cystic fibrosis and chronic obstructive pulmonary disease (COPD). (c) 2012 Optical Society of America
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available