Journal
BIOMEDICAL OPTICS EXPRESS
Volume 3, Issue 6, Pages 1215-1225Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.3.001215
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Funding
- Sir Peter and Lady Michael Foundation
- Canary Foundation
- Ben and Catherine Ivy Foundation
- NCI ICMIC [P50 CA114747]
- NCI CCNE-T [U54 U54CA151459, R01 CA160986]
- National Cancer Institute (NCI) [R01 CA128908]
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We demonstrate feasibility of endoscopic imaging of Cerenkov light originated when charged nuclear particles, emitted from radionuclides, travel through a biological tissue of living subjects at superluminal velocity. The endoscopy imaging system consists of conventional optical fiber bundle/ clinical endoscopes, an optical imaging lens system, and a sensitive low-noise charge coupled device (CCD) camera. Our systematic studies using phantom samples show that Cerenkov light from as low as 1 mu Ci of radioactivity emitted from F-18-Fluorodeoxyglucose (FDG) can be coupled and transmitted through conventional optical fibers and endoscopes. In vivo imaging experiments with tumor bearing mice, intravenously administered with F-18-FDG, further demonstrated that Cerenkov luminescence endoscopy is a promising new tool in the field of endoscopic molecular imaging. (C) 2012 Optical Society of America
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