Journal
BIOMEDICAL OPTICS EXPRESS
Volume 3, Issue 11, Pages 3012-3021Publisher
Optica Publishing Group
DOI: 10.1364/BOE.3.003012
Keywords
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Funding
- NSERC-CIHR CHRP program
- Ontario Ministry of Research and Innovation (MRI) through the Premier's Inaugural Discovery Award
- ORF program
- Canada Foundation for Innovation (CFI)
- Pranalytica Inc.
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Noninvasive glucose monitoring will greatly improve diabetes management. We applied Wavelength-Modulated Differential Laser Photothermal Radiometry (WM-DPTR) to noninvasive glucose measurements in human skin in vitro in the mid-infrared range. Glucose measurements in human blood serum diffused into a human skin sample (1 mm thickness from abdomen) in the physiological range (21-400 mg/dl) demonstrated high sensitivity and accuracy to meet wide clinical detection requirements. It was found that the glucose sensitivity could be tuned by adjusting the intensity ratio and phase difference of the two laser beams in the WM-DPTR system. The measurement results demonstrated the feasibility of the development of WM-DPTR into a clinically viable noninvasive glucose biosensor. (c) 2012 Optical Society of America
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