Journal
BIOMEDICAL OPTICS EXPRESS
Volume 2, Issue 2, Pages 385-395Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.2.000385
Keywords
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Funding
- National Institutes of Health [EB 008821, EB 008101]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0821312] Funding Source: National Science Foundation
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Magneto-photo-acoustic imaging, a technique based on the synergy of magneto-motive ultrasound, photoacoustic and ultrasound imaging, is introduced. Hybrid nanoconstructs, liposomes encapsulating gold nanorods and iron oxide nanoparticles, were used as a dual-contrast agent for magneto-photo-acoustic imaging. Tissue-mimicking phantom and macrophage cells embedded in ex vivo porcine tissue were used to demonstrate that magneto-photo-acoustic imaging is capable of visualizing the location of cells or tissues labeled with dual-contrast nanoparticles with sufficient contrast, excellent contrast resolution and high spatial resolution in the context of the anatomical structure of the surrounding tissues. Therefore, magneto-photo-acoustic imaging is capable of identifying the nanoparticle-labeled pathological regions from the normal tissue, providing a promising platform to noninvasively diagnose and characterize pathologies. (C) 2011 Optical Society of America
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