Journal
BIOMEDICAL OPTICS EXPRESS
Volume 2, Issue 8, Pages 2329-2338Publisher
Optica Publishing Group
DOI: 10.1364/BOE.2.002329
Keywords
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Funding
- National Natural Science Foundation of China [60637020, 60677012]
- Tianjin Foundation of Natural Science [09JCZDJC18300]
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By scanning biological tissues in vivo and in vitro with optical coherence tomography, it is found that liquid paraffin can enhance the percutaneous penetration of glycerol in deep layers of tissue and take synergistically optical clearing effect with glycerol. It is shown from experimental results that 30% - 50% liquid paraffin glycerol solutions have the best enhancement effect. Considering the refractive index of liquid paraffin and its medicinal value, we think liquid paraffin will play an important role in optical clearing as the penetration enhancer of glycerol in future clinical research. (C) 2011 Optical Society of America
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