Journal
BIOMEDICAL OPTICS EXPRESS
Volume 1, Issue 2, Pages 489-499Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.1.000489
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Funding
- National Institutes of Health (NIH) [R01 EB003682, R01 CA109861, R01 CA118794]
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Noninvasive optical techniques for tissue characterization, in particular, light scattering properties and blood supply quantification of mucosa, is useful in a wide variety of applications. However, fiber-optic probes that require contact with the tissue surface can present a challenging problem in the variability of in vivo measurements due the nature of interactions, for example affects due to variations in pressure applied to the probe tip. We present an in vivo evaluation of pressure, angle, and temporal effects on tissue properties for polarization-gated spectroscopy at superficial depths (within 100 to 200 microns of tissue surface) for oral mucosa. (C) 2010 Optical Society of America
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