Journal
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
Volume 5, Issue -, Pages 1477-1490Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjnano.5.161
Keywords
colloidal stability; intracellular particle distribution; nanoparticles; protein corona; toxicity of nanoparticles
Funding
- German Research Foundation (DFG) [SPP 1313, PA794/4-2]
- DFG [SPP 1313, NI291/7, NI291/8]
- Alexander von Humboldt Foundation
- Chinese Scholarship Council (CSC)
- Youssef Jameel Foundation
- NRL NSI
- DTRA
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The interfacing of colloidal nanoparticles with mammalian cells is now well into its second decade. In this review our goal is to highlight the more generally accepted concepts that we have gleaned from nearly twenty years of research. While details of these complex interactions strongly depend, amongst others, upon the specific properties of the nanoparticles used, the cell type, and their environmental conditions, a number of fundamental principles exist, which are outlined in this review.
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