Journal
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
Volume 10, Issue 5-6, Pages 448-456Publisher
KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
DOI: 10.4168/aair.2018.10.5.448
Keywords
Natural killer cells; inflammation; asthma; chronic obstructive pulmonary disease; allergic rhinitis; chronic rhinosinusitis
Categories
Funding
- Korean Healthy Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [A110893]
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2012R1A1A2020059]
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [2014R1A1A3050498]
- Korea Health Promotion Institute [A110893] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2012R1A1A2020059, 2014R1A1A3050498] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Natural killer (NK) cells have an immune regulatory function as well as cytotoxicity against tumor or infected cells. In the airway, although NK cells constitute a small proportion of the resident lymphocytes, they play an important role in the pathogenesis of chronic inflammatory airway diseases by modulating immune responses. NK cells can promote allergic airway inflammation by increasing the production of type 2 cytokines and inducing eosinophil migration. The increased activity of NK cells can develop or aggravate the destruction of lung parenchymal cells. On the other hand, decreased apoptotic activity of NK cells in eosinophils can serve as an aggravating factor for allergic airway inflammation. The increase in interferon-gamma-producing NK cells and the inhibition of type 2 immune response by NK cells can alleviate allergic airway inflammation. This review aims to define the roles of NK cells in chronic inflammatory diseases of lower and upper airways.
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