Journal
JAMA NEUROLOGY
Volume 72, Issue 7, Pages 823-829Publisher
AMER MEDICAL ASSOC
DOI: 10.1001/jamaneurol.2015.0608
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Categories
Funding
- Citizens United for Research in Epilepsy Taking Flight Award
- National Institutes of Health [K99NS087110, NS74432]
- Pediatric Scientist Development Program fellowship - March of Dimes
- Human Frontier Science Program [MH54671, NS074015]
- G. Harold & Leila Y. Mathers Charitable Foundation
- National Institutes of Health Brain Research Through Advancing Innovative Neurotechnologies Initiative [NS090583]
- Temporal Dynamics of Learning Center grant from the National Science Foundation [SBE-0542013]
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Brain-implanted devices are no longer a futuristic idea. Traditionally, therapies for most neurological disorders are adjusted based on changes in clinical symptoms and diagnostic measures observed over time. These therapies are commonly pharmacological or surgical, requiring continuous or irreversible treatment regimens that cannot respond rapidly to fluctuations of symptoms or isolated episodes of dysfunction. In contrast, closed-loop systems provide intervention only when needed by detecting abnormal neurological signals and modulating them with instantaneous feedback. Closed-loop systems have been applied to several neurological conditions (most notably epilepsy and movement disorders), but widespread use is limited by conceptual and technical challenges. Herein, we discuss how advances in experimental closed-loop systems hold promise for improved clinical benefit in patients with neurological disorders.
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