Journal
ACS COMBINATORIAL SCIENCE
Volume 16, Issue 4, Pages 192-197Publisher
AMER CHEMICAL SOC
DOI: 10.1021/co400164z
Keywords
sulfonamides; sulfonyl fluorides; sulfonyl chlorides; saturated compounds; parallel synthesis
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Two types of aliphatic sulfonyl halides (Cl versus F) were compared in parallel synthesis of sulfonamides derived from aliphatic amines. Aliphatic sulfonyl fluorides showed good results with amines bearing an additional functionality, while the corresponding chlorides failed. Both sulfonyl halides were effective in the reactions with amines having an easily accessible amino group. Aliphatic sulfonyl chlorides reacted efficiently with amines bearing sterically hindered amino group while the corresponding fluorides showed low activity.
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