4.0 Article

2-Methylindole as an Indicative Nucleophile for Developing a Three-Component Reaction of Aldehyde with Two Different Nucleophiles

Journal

ACS COMBINATORIAL SCIENCE
Volume 16, Issue 6, Pages 287-292

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/co500010x

Keywords

2-methylindole; indicative nucleophile; three-component reaction

Funding

  1. National Natural Science Foundation of China [21373093, 21173089]
  2. Cooperative Innovation Center of Hubei Province
  3. Chutian Scholar Program of the Hubei Provincial Government

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2-Methylindole was used as an indicative nucleophile for rapid screening of MCRs of aldehydes with two different nucleophiles. By removal of some samples that have characteristic color associated with the generation of di(indolyOmethane derivatives the difficulties encountered in the product analysis were alleviated significantly.

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