Journal
ACS COMBINATORIAL SCIENCE
Volume 16, Issue 4, Pages 184-191Publisher
AMER CHEMICAL SOC
DOI: 10.1021/co4001309
Keywords
indole; diversity-oriented synthesis; drug-like; privileged structure; microwave
Funding
- National Natural Science Foundation of China [21021063, 91229204, 81025017]
- National S&T Major Projects [2012ZX09103101-072, 2012ZX09301001-005]
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A library of privileged-substructure-based, heterocyclic compounds was constructed by a sequence of Ugi four-component reactions incorporating the indole motif and microwave-assisted cyclizations in branched pathways. Cheminformatic analysis confirmed that the library exhibited a high degree of structural diversity and good drug-likeness.
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