Journal
ACS COMBINATORIAL SCIENCE
Volume 15, Issue 9, Pages 512-518Publisher
AMER CHEMICAL SOC
DOI: 10.1021/co400080z
Keywords
multicomponent reaction; spirooxindole; magnetic catalyst; supported acidic ionic liquid
Funding
- Shiraz University
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Magnetic, supported acidic ionic liquid was synthesized and identified as an efficient catalyst for the one-pot synthesis of novel spirooxindole derivatives at mild conditions and in good yields. Three component reaction of wide variety of substituted isatins, 1,3-dimethyl-2-amino uracil, and barbituric acid, thiobarbituric acid, and dimedon as 1,3-dicarbonyl compounds gives the target compounds. Operational simplicity, low cost, high yields, environmental friendliness, wide applicability and reusability and easy recovery of the catalyst using an external magnet are the key features of this methodology.
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