Journal
ACS COMBINATORIAL SCIENCE
Volume 14, Issue 3, Pages 164-169Publisher
AMER CHEMICAL SOC
DOI: 10.1021/co200195t
Keywords
peptoids; one bead one compound libraries; heterocycles; solid-phase synthesis; peptidomimetics
Funding
- National Institutes of Health [1RO1 GM 090294]
- National Heart Lung and Blood Institute [NO1-HV-00242]
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Combinatorial libraries of peptoids (oligo-N-substituted glycines) have proven to be useful sources of protein ligands. Each unit of the peptoid oligomer is derived from 2-haloacetic acid and a primary amine. To increase the chemical diversity available in peptoid libraries, we demonstrate here that heterocyclic halomethyl carboxylic acids can be employed as backbone building blocks in the synthesis of peptoid-based oligomers. Optimized conditions are reported that allow the creation of large, high quality combinatorial libraries containing these units.
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