Journal
ACS COMBINATORIAL SCIENCE
Volume 14, Issue 5, Pages 335-341Publisher
AMER CHEMICAL SOC
DOI: 10.1021/co3000264
Keywords
one-pot synthesis; three-component reaction; spirooxindole-pyrimidine derivatives; functionalized silica-coated magnetic nanoparticles
Funding
- National Natural Science Foundation of China [21072042, 20872025, 30873139]
- Nature Science Foundation of Hebei Province [B2011205031]
- National Basic Research Program of China [2011CB512007, 2012CB723501]
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Dodecyl benzenesulfonic acid functionalized silica-coated magnetic nanoparticles (gamma-Fe2O3@SiO2-DDBSA) were readily prepared and identified as an efficient catalyst for the synthesis of a library of spirooxindole-pyrimidine derivatives by three-component condensation reaction of barbituric acids, isatins and cyclohexane-1,3-diones. The aqueous reaction medium, easy recovery of the catalyst using an external magnet, and high yields make the protocol sustainable and economic.
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