Journal
ACS COMBINATORIAL SCIENCE
Volume 13, Issue 4, Pages 405-413Publisher
AMER CHEMICAL SOC
DOI: 10.1021/co2000357
Keywords
integrated flow; trisubstituted pyrrolidines; focused library
Funding
- Ralph Raphael studentship award
- Cambridge European Trust
- F. Hoffmann-La Roche Ltd. Basel
- Royal Society
- BP endowment
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A combination of flow and batch chemistries has been successfully applied to the assembly of a series of trisub-stituted drug-like pyrrolidines. This study demonstrates the efficient preparation of a focused library of these pharmaceutically important structures using microreactor technologies, as well as classical parallel synthesis techniques, and thus exemplifies the impact of integrating innovative enabling tools within the drug discovery process.
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