Journal
ACS COMBINATORIAL SCIENCE
Volume 13, Issue 2, Pages 120-125Publisher
AMER CHEMICAL SOC
DOI: 10.1021/co100026y
Keywords
three-component reaction; 2-alkynlbenzaldoxime; carbodiimide; Suzuki-Miyaura coupling; 1-(isoquinolin-1-yl)ureas; palladium-catalyzed
Funding
- National Natural Science Foundation of China [20972030]
- Science & Technology Commission of Shanghai Municipality [09JC1404902]
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A novel and highly efficient three-component reaction of 2-alkynylbenzaldoxime, carbodiimide, with electrophile (bromine or iodine monochloride) is disclosed, which generates 1-(4-haloisoquinolin-1-yl)ureas in good yields under mild conditions. Subsequent palladium-catalyzed Suzuki-Miyaura coupling reaction is introduced, leading to the diverse 1-(isoquinolin-1-yl)ureas.
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