Journal
ACS CATALYSIS
Volume 4, Issue 8, Pages 2741-2745Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cs500813z
Keywords
axial chirality; iodination; kinetic resolution; N-oxide; Pd(II)-catalyzed
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Funding
- National Basic Research Program of China (973 Program) [2010CB833300]
- National Natural Science Foundation of China [21025209, 21121062, 21272253, 21332009]
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An efficient protocol to synthesize axially chiral compounds via kinetic resolution by Pd(II)-catalyzed direct C H iodination was realized (up to s = 27). The iodide product could be easily transformed to aryl-substituted pyridine N-oxides via the Suzuki Miyaura coupling, which proved to be a suitable catalyst in asymmetric allylation of benzaldehyde with allyltrichlorosilane.
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