Journal
ACS CATALYSIS
Volume 3, Issue 6, Pages 1406-1410Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cs400232b
Keywords
aminocarbonylation; carbonylation; palladium nanoparticles; heterogeneous catalysis; ZIF-8; amide synthesis
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Funding
- GSK-EDB Singapore Partnership for Green and Sustainable Manufacturing
- Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), Singapore
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Pd nanoparticles supported on ZIF-8 (PdNPs/ZIF-8) are described as an efficient heterogeneous catalyst for the aminocarbonylation of bromoarenes in the presence of phosphines and iodoarenes under phosphine-free conditions. The catalyst can be readily prepared and is air-stable. The palladium loading can be as low as 1 wt %, and the catalyst was recycled four times with negligible change in catalytic performance. A variety of pharmaceutically important amides was readily synthesized. A TON of 2540 was easily achieved in a batch reaction by scaling up to a gram scale. The catalyst reported can also be applied to the synthesis of cyclic and primary amides as well as an alkoxycarbonylation reaction to form an ester.
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