Journal
ACS CATALYSIS
Volume 3, Issue 4, Pages 502-506Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cs300806w
Keywords
trifluoromethyl; organocatalyst; Michael addition; fluorine; asymmetric
Categories
Funding
- National Basic Research Program of China [2012CB821600, 2010CB126103]
- Key Program of National Natural Science Foundation of China [21032006]
- National Natural Science Foundation of China [21172244/21172245/B020304]
- Agro-scientific Research in the Public Interest [201103007]
- National Key Technologies RD Program [2011BAE06B05]
- Shanghai Scientific Research Program [10XD1405200]
- Shanghai Pujiang program [11PJ1412200]
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An organocatalytic asymmetric Michael addition of nitroalkanes to trifluoromethylated acrylamides in good yields and with good to excellent diastereoselectivities and excellent enantioselectivities is described. The Michael adducts could be readily transformed into optically pure trifluoromethylated gamma-aminobutyric acid 7 in high yields without loss in enantioselectivities.
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