Journal
NATURE COMMUNICATIONS
Volume 9, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-06102-7
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Funding
- New York Stem Cell Foundation
- US National Institutes of Health [R01NS095280, R01NS093357, F31NS083354]
- CWRU SOM Light Microscopy Core Facility [S10-OD016164]
- Genomics core facility of the Case Comprehensive Cancer Center [P30CA043703]
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Oligodendrocyte dysfunction underlies many neurological disorders, but rapid assessment of mutation-specific effects in these cells has been impractical. To enable functional genetics in oligodendrocytes, here we report a highly efficient method for generating oligodendrocytes and their progenitors from mouse embryonic and induced pluripotent stem cells, independent of mouse strain or mutational status. We demonstrate that this approach, when combined with genome engineering, provides a powerful platform for the expeditious study of genotype-phenotype relationships in oligodendrocytes.
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