Journal
NATURE COMMUNICATIONS
Volume 9, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-05427-7
Keywords
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Categories
Funding
- NHMRC [1031333, 1109286, APP1061779, APP1111246, 339435, 552402]
- Joseph Mitchell Trust
- Cancer Research UK
- Oxford Comprehensive Biomedical Research Center
- European Community's Seventh Framework Programme [223175 (HEALTH-F2-2009-223175)]
- Cancer Research UK [C1287/A10118, C1287/A10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565, C490/A10124, C1287/A12014]
- National Institutes of Health [CA128978]
- Post-Cancer GWAS initiative [1U19 CA148537, 1U19 CA148065, 1U19 CA148112]
- Department of Defence [W81XWH-10-1-0341]
- Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer
- Komen Foundation for the Cure
- Breast Cancer Research Foundation
- Ovarian Cancer Research Fund
- US National Institutes of Health [CA1X01HG007491-01, U19-CA148112, R01-CA149429, R01-CA058598]
- Canadian Institutes of Health Research [MOP-86727]
- Genome Canada [GPH-129344]
- NIH [U19 CA148065]
- Cancer UK [C1287/A16563]
- Cancer Council Queensland [4196615]
- Cancer Council Tasmania [403031, 457636]
- Medical Research Council [G0000934]
- Wellcome Trust [068545/Z/02, 085475]
- EU FP7 CHIBCHA grant
- Wellcome Trust Centre for Human Genetics Core Grant [090532/Z/09Z]
- NHMRC
- University of Newcastle
- Gladys M Brawn Senior Research Fellowship scheme
- Vincent Fairfax Family Foundation
- Hunter Medical Research Institute
- Hunter Area Pathology Service
- ELAN fund of the University of Erlangen
- Rudolf Bartling Foundation
- Verelst Foundation for endometrial cancer
- National Cancer Institute of United States Public Health Service [R01 CA122443, P30 CA15083, P50 CA136393]
- National Cancer Institute of United States Public Health Service (GAME-ON the NCI Cancer Post-GWAS Initiative) [U19 CA148112]
- Fred C and Katherine B Andersen Foundation
- Mayo Foundation
- Smith family
- Helse Vest Grant the University of Bergen
- Melzer Foundation
- Norwegian Cancer Society (Harald Andersens legat)
- Research Council of Norway
- Haukeland University Hospital
- Stockholm County Council
- Karolinska Institutet [20110222, 20110483, 20110141, DF07015]
- Swedish Labor Market Insurance [100069]
- Swedish Cancer Society [11 0439]
- Agency for Science, Technology and Research of Singapore (A*STAR)
- US National Institutes of Health
- Susan G. Komen Breast Cancer Foundation
- National Heart, Lung, and Blood Institute
- US Department of Health and Human Services [HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, HHSN271201100004C]
- NCI [U19 CA148065-01]
- NCI, NIH [UM1 CA186107, P01 CA087969, R01 CA49449, 1R01 CA134958, 2R01 CA082838, RO1CA98346, NIH RO1 CA105212, RO1 CA 87538, RO1 CA75977, RO3 CA80636, NO1 HD23166, R35 CA39779, KO5 CA92002, CA54281, CA128008, R01 CA91019, R01 CA77398]
- Fred Hutchinson Cancer Research Center
- California Breast Cancer Research Fund [97-10500]
- Intramural Research Program of the NCI
- NCI
- National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services [HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, HHSN268201600004C]
- UK National Institute for Health Research Biomedical Research Centres at the University of Cambridge
- [2682012000081]
- MRC [MC_UU_12015/2] Funding Source: UKRI
Ask authors/readers for more resources
Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.
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