Journal
NATURE COMMUNICATIONS
Volume 5, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms5593
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Funding
- Interdisciplinary Center of Clinical Research of the University of Muenster [Vo2/014/09]
- German Research Foundation (DFG) [EI 878 1-1]
- European Union [CRC 656 A09, CRC 1009 B8, B9, 305266]
- Federal Ministry of Education and Research (BMBF)
- CR-UK [C1519/A6906]
- KCL-UCL Comprehensive Cancer Imaging Centre CR-UK
- EPSRC
- MRC
- DoH
- MRC [MR/L001640/1] Funding Source: UKRI
- Cancer Research UK [16463] Funding Source: researchfish
- Medical Research Council [MR/L001640/1] Funding Source: researchfish
- ReumaFonds [13-3-402] Funding Source: researchfish
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Inflammation has a key role in the pathogenesis of various human diseases. The early detection, localization and monitoring of inflammation are crucial for tailoring individual therapies. However, reliable biomarkers to detect local inflammatory activities and to predict disease outcome are still missing. Alarmins, which are locally released during cellular stress, are early amplifiers of inflammation. Here, using optical molecular imaging, we demonstrate that the alarmin S100A8/S100A9 serves as a sensitive local and systemic marker for the detection of even sub-clinical disease activity in inflammatory and immunological processes like irritative and allergic contact dermatitis. In a model of collagen-induced arthritis, we use S100A8/S100A9 imaging to predict the development of disease activity. Furthermore, S100A8/S100A9 can act as a very early and sensitive biomarker in experimental leishmaniasis for phagocyte activation linked to an effective Th1-response. In conclusion, the alarmin S100A8/S100A9 is a valuable and sensitive molecular target for novel imaging approaches to monitor clinically relevant inflammatory disorders on a molecular level.
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