Journal
NATURE COMMUNICATIONS
Volume 5, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms5785
Keywords
-
Categories
Funding
- Department of Defense DTRA [HDTRA-11-1-0010, HDTRA1-12-C-0058]
- DoD/CDRMP Innovator Award
- National Science Foundation [MCB-1243082, MCB-940914]
- HealthTell Inc.
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1243082] Funding Source: National Science Foundation
Ask authors/readers for more resources
There is an increasing awareness that health care must move from post-symptomatic treatment to presymptomatic intervention. An ideal system would allow regular inexpensive monitoring of health status using circulating antibodies to report on health fluctuations. Recently, we demonstrated that peptide microarrays can do this through antibody signatures (immunosignatures). Unfortunately, printed microarrays are not scalable. Here we demonstrate a platform based on fabricating microarrays (similar to 10 M peptides per slide, 330,000 peptides per assay) on silicon wafers using equipment common to semiconductor manufacturing. The potential of these microarrays for comprehensive health monitoring is verified through the simultaneous detection and classification of six different infectious diseases and six different cancers. Besides diagnostics, these high-density peptide chips have numerous other applications both in health care and elsewhere.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available