Journal
NATURE COMMUNICATIONS
Volume 5, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms4465
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Funding
- FWF-Austrian Science Fund [L590-B12, P21292-B09]
- Cancer Society of Finland
- GBPM graduate school
- Vienna Science and Technology Fund (WWTF) [MA09-004]
- Academy of Finland (AKA) [120098, 120098] Funding Source: Academy of Finland (AKA)
- Austrian Science Fund (FWF) [P21292] Funding Source: Austrian Science Fund (FWF)
- Cancer Foundation Finland sr [110091, 120098] Funding Source: researchfish
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In cancers with a highly altered genome, distinct genetic alterations drive subsets rather than the majority of individual tumours. Here we use a sequential search across human tumour samples for transcript outlier data points with associated gene copy number variations that correlate with patient's survival to identify genes with pro-invasive functionality. Employing loss and gain of function approaches in vitro and in vivo, we show that one such gene, MTSS1, promotes the ability of melanocytic cells to metastasize and engages actin dynamics via Rho-GTPases and cofilin in this process. Indeed, high MTSS1 expression defines a subgroup of primary melanomas with unfavourable prognosis. These data underscore the biological, clinical and potential therapeutic implications of molecular subsets within genetically complex cancers.
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