4.8 Article

A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Resistance Mutations Against HCV Protease Inhibitors and Antiviral Drug Design

Luqing Shang et al.

CURRENT PHARMACEUTICAL DESIGN (2014)

Article Biochemistry & Molecular Biology

Negative selection and stringency modulation in phage-assisted continuous evolution

Jacob C. Carlson et al.

NATURE CHEMICAL BIOLOGY (2014)

Review Gastroenterology & Hepatology

New therapeutic strategies in HCV: second-generation protease inhibitors

Virginia C. Clark et al.

LIVER INTERNATIONAL (2013)

Review Biotechnology & Applied Microbiology

Novel therapies for hepatitis C - one pill fits all?

Michael P. Manns et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Article Multidisciplinary Sciences

Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution

Bryan C. Dickinson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Engineering of TEV protease variants by yeast ER sequestration screening (YESS) of combinatorial libraries

Li Yi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Microbiology

Resistance Analysis of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir

Fiona McPhee et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)

Review Biochemistry & Molecular Biology

Proteases as therapeutics

Charles S. Craik et al.

BIOCHEMICAL JOURNAL (2011)

Article Multidisciplinary Sciences

A system for the continuous directed evolution of biomolecules

Kevin M. Esvelt et al.

NATURE (2011)

Article Biochemistry & Molecular Biology

Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease

Daniel C. Gray et al.

Review Biochemistry & Molecular Biology

Design of next-generation protein therapeutics

Justin Caravella et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2010)

Article Multidisciplinary Sciences

Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding

Keith P. Romano et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Cell Biology

Rapid Emergence of Protease Inhibitor Resistance in Hepatitis C Virus

Libin Rong et al.

SCIENCE TRANSLATIONAL MEDICINE (2010)

Article Biochemistry & Molecular Biology

Engineering of protease variants exhibiting altered substrate specificity

Saravanan Sellamuthu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Article Biotechnology & Applied Microbiology

Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites

Oliver Schilling et al.

NATURE BIOTECHNOLOGY (2008)

Article Biochemistry & Molecular Biology

Highly active and selective endopeptidases with programmed substrate specificities

Navin Varadarajan et al.

NATURE CHEMICAL BIOLOGY (2008)

Article Chemistry, Multidisciplinary

A remodelled protease that cleaves phosphotyrosine substrates

Zachary A. Knigh et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

Article Biochemical Research Methods

Monitoring regulated protein-protein interactions using split TEV

Michael C. Wehr et al.

NATURE METHODS (2006)

Article Biotechnology & Applied Microbiology

Biopharmaceutical benchmarks 2006

Gary Walsh

NATURE BIOTECHNOLOGY (2006)

Review Biotechnology & Applied Microbiology

Targeting proteases: successes, failures and future prospects

Boris Turk

NATURE REVIEWS DRUG DISCOVERY (2006)

Article Multidisciplinary Sciences

Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity

N Varadarajan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Identification of mutator genes and mutational pathways in Escherichia coli using a multicopy cloning approach

HJ Yang et al.

MOLECULAR MICROBIOLOGY (2004)

Review Biochemistry & Molecular Biology

Immunotherapy: past, present and future

TA Waldmann

NATURE MEDICINE (2003)

Article Biochemistry & Molecular Biology

Predicting the emergence of antibiotic resistance by directed evolution and structural analysis

MC Orencia et al.

NATURE STRUCTURAL BIOLOGY (2001)