Journal
NATURE COMMUNICATIONS
Volume 4, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms3049
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Funding
- BBSRC
- Medical Research Council of Great Britain [G0300241, G0501618]
- National Institute of Health [DK R37 28082, P01DK56116]
- German Research Council [870]
- Deutsche Forschungsgemeinschaft [SPP1109, TA-310-1, TA-310-2]
- Medical Research Council [G0501618, G0300241] Funding Source: researchfish
- MRC [G0501618, G0300241] Funding Source: UKRI
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Emerging evidence suggests that new cells, including neurons, can be generated within the adult hypothalamus, suggesting the existence of a local neural stem/progenitor cell niche. Here, we identify alpha-tanycytes as key components of a hypothalamic niche in the adult mouse. Long-term lineage tracing in vivo using a GLAST::CreER(T2) conditional driver indicates that alpha-tanycytes are self-renewing cells that constitutively give rise to new tanycytes, astrocytes and sparse numbers of neurons. In vitro studies demonstrate that alpha-tanycytes, but not beta-tanycytes or parenchymal cells, are neurospherogenic. Distinct subpopulations of alpha-tanycytes exist, amongst which only GFAP-positive dorsal alpha 2-tanycytes possess stem-like neurospherogenic activity. Fgf-10 and Fgf-18 are expressed specifically within ventral tanycyte subpopulations; alpha-tanycytes require fibroblast growth factor signalling to maintain their proliferation ex vivo and elevated fibroblast growth factor levels lead to enhanced proliferation of alpha-tanycytes in vivo. Our results suggest that alpha-tanycytes form the critical component of a hypothalamic stem cell niche, and that local fibroblast growth factor signalling governs their proliferation.
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