Journal
NATURE COMMUNICATIONS
Volume 4, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms2433
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Funding
- Beijing Natural Science Foundation [7111005]
- Beijing Municipal Science and Technology Commission [D09050703560902, D09050703560903]
- National S&T Major Project for Infectious Diseases Control [2012ZX10001006-001-008]
- Beijing Youan Hepatitis/AIDS foundation [BJYAH-2011-021]
- National Natural Science Foundation of China [81271842, 81228020]
- Wellcome Trust Sanger Institute
- Medical Research Council, UK
- Medical Research Council [G0600371, G1001046, G0600520] Funding Source: researchfish
- National Institute for Health Research [DHCS/04/G121/68] Funding Source: researchfish
- MRC [G1001046, G0600520, G0600371] Funding Source: UKRI
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The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection. Specifically, the CC genotype was estimated to confer a sixfold greater risk for severe infection than the CT and TT genotypes. More importantly, because the risk genotype occurs with such a high frequency, its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied compared with 5.4% in Northern Europeans. Interferon-induced transmembrane protein-3 genetic variants could, therefore, have a strong effect of the epidemiology of influenza in China and in people of Chinese descent.
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