Journal
NATURE COMMUNICATIONS
Volume 4, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms3613
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Funding
- Program for Promotion of Basic Research Activities for Innovative Biosciences (PROBRAIN)
- Japan Society for the Promotion of Science (JSPS)
- Core Research for Evolutional Science and Technology (CREST) Program of Japan Science and Technology Agency (JST)
- Targeted Proteins Research Program (TPRP) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT)
- Grants-in-Aid for Scientific Research [12J04840, 23228003, 24114003, 20001009] Funding Source: KAKEN
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Strigolactones (SLs) are phytohormones that inhibit shoot branching and function in the rhizospheric communication with symbiotic fungi and parasitic weeds. An alpha/beta-hydrolase protein, DWARF14 (D14), has been recognized to be an essential component of plant SL signalling, although its precise function remains unknown. Here we present the SL-dependent interaction of D14 with a gibberellin signalling repressor SLR1 and a possible mechanism of phytohormone perception in D14-mediated SL signalling. D14 functions as a cleavage enzyme of SLs, and the cleavage reaction induces the interaction with SLR1. The crystal structure of D14 shows that 5-hydroxy-3-methylbutenolide (D-OH), which is a reaction product of SLs, is trapped in the catalytic cavity of D14 to form an altered surface. The D14 residues recognizing D-OH are critical for the SL-dependent D14 - SLR1 interaction. These results provide new insight into crosstalk between gibberellin and SL signalling pathways.
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