Journal
NATURE COMMUNICATIONS
Volume 4, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms2796
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Funding
- Australian National Health and Medical Research Council (NHRMC)
- Human Frontiers Science Program
- Australian Research Council (ARC)
- Australian Cancer Research Foundation (ACRF, ACRF Cell Biology Program)
- NIH [R01AI093870]
- MRC UK [U117573801]
- MRC [MC_U117573801, MC_PC_13055] Funding Source: UKRI
- Medical Research Council [MC_U117573801, MC_PC_13055] Funding Source: researchfish
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The production of protective antibody requires effective signalling of naive B cells following encounter with antigen, and the divergence of responding B lymphocytes into distinct lineages. Polarity proteins have recently been proposed as important mediators of both the initial B cell response, and potentially of asymmetric cell division. Here we show that, although polarity proteins of the Scribble complex, Scribble, Dlg1 and Lgl1, are expressed and polarized during early B cell activation, their deficiency has no effect on the in vivo outcome of immunization or challenge with influenza infection. Furthermore, we find a striking correlation in the differentiation outcome of daughters of single founder B cells in vitro. Taken together, our results indicate that B cell differentiation does not require polarity proteins of the Scribble complex, and the findings do not support a role for asymmetric cell division in B cell activation and differentiation.
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