Journal
NATURE COMMUNICATIONS
Volume 4, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/ncomms2656
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Funding
- Australian Research Council [LP0882622]
- Deutsche Forschungsgemeinschaft [Al 287/7-1, Me 3245/1-1]
- National Geographic's Genographic Project
- Netherlands Forensic Institute (NFI)
- Netherlands Genomics Initiative (NGI)/Netherlands Organization for Scientific Research (NWO) within the framework of the Forensic Genomics Consortium Netherlands (FGCN)
- Australian Research Council [LP0882622] Funding Source: Australian Research Council
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Haplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (similar to 19%) among Early Neolithic farmers (similar to 5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we investigate this major component of the maternal population history of modern Europeans and sequence 39 complete haplogroup H mitochondrial genomes from ancient human remains. We then compare this 'real-time' genetic data with cultural changes taking place between the Early Neolithic (similar to 5450 BC) and Bronze Age (similar to 2200 BC) in Central Europe. Our results reveal that the current diversity and distribution of haplogroup H were largely established by the Mid Neolithic (similar to 4000 BC), but with substantial genetic contributions from subsequent pan-European cultures such as the Bell Beakers expanding out of Iberia in the Late Neolithic (similar to 2800 BC). Dated haplogroup H genomes allow us to reconstruct the recent evolutionary history of haplogroup H and reveal a mutation rate 45% higher than current estimates for human mitochondria.
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