Journal
NATURE COMMUNICATIONS
Volume 2, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms1585
Keywords
-
Categories
Funding
- Swiss Cancer League [OCS-02017-02-2007]
- Swiss National Science Foundation [3100A0-109340, 310030_132884/1, 3100A0-118093]
- Wilhelm Sander Stiftung
- Gottfried and Julia Bangerter Rhyner Stiftung
- National Institute of Health [AI 36964]
- Deutsche Dermatologische Gesellschaft
- Arbeitsgemeinschaft Dermatologische Forschung
- European Community [PIEF-GA-2009-235322]
Ask authors/readers for more resources
Activin is an important orchestrator of wound repair, but its potential role in skin carcinogenesis has not been addressed. Here we show using different types of genetically modified mice that enhanced levels of activin in the skin promote skin tumour formation and their malignant progression through induction of a pro-tumourigenic microenvironment. This includes accumulation of tumour-promoting Langerhans cells and regulatory T cells in the epidermis. Furthermore, activin inhibits proliferation of tumour-suppressive epidermal gamma delta T cells, resulting in their progressive loss during tumour promotion. An increase in activin expression was also found in human cutaneous basal and squamous cell carcinomas when compared with control tissue. These findings highlight the parallels between wound healing and cancer, and suggest inhibition of activin action as a promising strategy for the treatment of cancers overexpressing this factor.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available