Journal
ONCOLOGY LETTERS
Volume 9, Issue 3, Pages 1027-1033Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2014.2816
Keywords
microRNA; hepatocellular carcinoma; diagnosis; therapy
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Funding
- National Natural Science Foundation of China [81101824]
- Outstanding Youth Science Foundation of Tongji Hospital [YXQN005]
- Youth Sciences and Technology Chenguang Planning of Wuhan [2014070404010219]
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Hepatocellular carcinoma is a type of cancer characterized by significant morbidity and high mortality rates worldwide. Previous studies have revealed that alterations in microRNA (miRNA) expression are a common feature of cancer. Furthermore, as evolutionarily conserved, non-encoding RNAs, miRNAs have demonstrated fundamental roles in the various biological processes involved in cancer. Genome-wide miRNA expression profile studies and bioinformatic methods have provided comprehensive insight into the role of cancer-related miRNAs. In addition, investigation of the function and mechanisms of miRNAs has provided an understanding of the association with the pathogenesis of cancer. In the present review, the tumor-promoting or tumor-suppressive roles and underlying mechanisms of certain significant miRNAs at a single and integral level are summarized. Furthermore, the recognition of miRNA-gene networks and current advances in the potential use of miRNA-based diagnosis and therapy are discussed.
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