Journal
ONCOLOGY LETTERS
Volume 4, Issue 6, Pages 1234-1240Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2012.895
Keywords
adenoid cystic carcinomas; recurrence; immunohistochemistry; glucose transporter-1; PI3K/Akt pathway
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Funding
- Department of Health Bureau, Zhejiang, China [2009B042]
- Science and Technology Department of Zhejiang Province [2009C33026]
- National Natural Science Foundation of China [81172562]
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The purpose of this study was to explore the factors associated with the recurrence of adenoid cystic carcinomas (ACCs). We examined the recurrence values of clinicopathological variables and GLUT-1, p-Akt and PI3K expression in 42 patients with ACC. Of the 42 patients, 17 developed recurrence following initial surgery. The positive rates of GLUT-I, PI3K and p-Akt protein expression in ACC were 38.1, 38.1 and 50.0%, respectively. The expression of GLUT-1, p-Akt or PI3K protein in ACC was higher than that in inflammatory lesions or benign tumors. Our study demonstrated that T stage, a positive resection margin, perineural invasion, surgery without postoperative radiotherapy and the expression of GLUT-1, PI3K and p-Akt were factors predictive of recurrence by univariate analyses. In multivariate analyses, perineural invasion, a positive resection margin and p-Akt were significant predictors of recurrence. Initial surgery is very significant in the recurrence of ACC. Overexpression of GLUT-1, PI3K and p-Akt may also play a role in its development and recurrence.
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