Journal
ONCOLOGY LETTERS
Volume 1, Issue 2, Pages 227-230Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol_00000040
Keywords
cytochrome c; gene expression profiling; diffuse large B cell lymphoma; mantle-cell lymphoma; follicular lymphoma
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Funding
- NCI [CA71768, NCI-T32 CA09213, HHM1 52003749]
- ARCS Foundation
- NATIONAL CANCER INSTITUTE [R01CA071768, P30CA023074, R29CA071768, T32CA009213] Funding Source: NIH RePORTER
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Mitochondria are central to a variety of cellular processes, from metabolism to cell death In this study, we demonstrated that an increase in the critical mitochondrial protein, cytochrome c, correlated with drug resistance in a cell culture model of aggressive lymphoma Increased cytochrome, c expression was also correlated with decreased survival in the aggressive diffuse large B-cell and mantle cell lymphomas, but not in the indolent follicular lymphoma This suggests that an increased reliance on the mitochondria for energy allows tumor cells to be metabolic opportunists and contribute to tumor development and drug resistance
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