Journal
EPIGENOMICS
Volume 6, Issue 3, Pages 267-275Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/EPI.14.18
Keywords
cell death; DNA methylation; DNMT1; DNMT inhibitor; epigenetic; glioblastoma; glioma
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Funding
- Canceropole Grand Ouest/Region Pays de la Loire
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Aim: DNA methylation is a fundamental biologic process of genomes and is a candidate for pharmacological manipulation that might have important therapeutic advantages. Thus, DNA methyltransferases (DNMTs) appear to be ideal targets for drug intervention. Materials & methods: To develop a new generation of DNMT inhibitor, we analyzed the ability of peptides to selectively inhibit certain DNMT1-incuding complexes. Results: Our study demonstrates that the disruption of DNMT1/CFP1-including complexes increases the efficiency of chemotherapeutic treatment on established tumors in mice. Conclusion: Our data opens a promising and innovative alternative to the development of DNMT inhibitors.
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