Journal
EPIGENETICS & CHROMATIN
Volume 6, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1756-8935-6-24
Keywords
Histone post-translational modifications; Mass spectrometry; Proteomics; Epigenetics
Categories
Funding
- NIH Innovator grant from the Office of the Director [DP2OD007447]
- National Science Foundation (NSF) Early Faculty CAREER award
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1262672] Funding Source: National Science Foundation
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Histone post-translational modifications (PTMs) have been linked to a variety of biological processes and disease states, thus making their characterization a critical field of study. In the last 5 years, a number of novel sites and types of modifications have been discovered, greatly expanding the histone code. Mass spectrometric methods are essential for finding and validating histone PTMs. Additionally, novel proteomic, genomic and chemical biology tools have been developed to probe PTM function. In this snapshot review, proteomic tools for PTM identification and characterization will be discussed and an overview of PTMs found in the last 5 years will be provided.
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