Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 9, Issue 10, Pages 953-955Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.8b00351
Keywords
CCR4; CCR4 antagonist; T-reg migration
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Recruitment of naturally occurring suppressive CD4(+), CD25+, and FOXP3(+) regulatory T cells (T-reg) to the tumor microenvironment (TME) has the potential to weaken the antitumor response in patients receiving treatment with immuno-oncology (IO) agents. Human T-reg express CCR4 and can be recruited to the TME through the C-C chemokines CCL17 and CCL22. We have recently developed a series of potent, orally bioavailable small molecule antagonists of CCR4 that can block recruitment of T-reg into the TME.
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