Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 5, Issue 12, Pages 1324-1328Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ml500399r
Keywords
Carbon monoxide; photoactive metal carbonyls; CO delivery; apoptosis; fluorescence tracking
Categories
Funding
- NSF [DMR-140933]
- Direct For Mathematical & Physical Scien [1409335] Funding Source: National Science Foundation
- Division Of Materials Research [1409335] Funding Source: National Science Foundation
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A designed photoactive CO releasing molecule (photoCORM), namely, fac-[MnBr(CO)(3)(pbt)] (1, pbt = 2-(2-pyridyl)benzothiazole), promotes CO-induced death of MDA-MB-231 human breast cancer cells upon illumination with broadband visible light. The CO release from this photoCORM can be tracked by rise in fluorescence within the cellular matrix due to deligation of the pbt ligand. The results of this study suggest the potential of 1 in eradication of cancer cells through CO delivery.
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