Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 3, Issue 2, Pages 165-169Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ml2003058
Keywords
GPR35; natural phenols; ellagic acid; biased agonism
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We report the discovery and characterization of natural phenols as G protein-coupled receptor-35 (GPR35) agonists. Pharmacological characterization using label-free dynamic mass redistribution and Tango beta-arrestin translocation assays revealed that GPR35-active natural phenols are divergent in their biased agonism.
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