Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 3, Issue 5, Pages 427-432Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ml300055n
Keywords
Nuclear receptors; RXR; partial agonists; type 2 diabetes
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Funding
- Ministry of Health, Labour, and Welfare of Japan [23080401]
- Ministry of Education, Science, Culture and Sports of Japan
- Takeda Science Foundation
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Treating insulin resistance and type 2 diabetes in rodents, currently known retinoid X receptor (RXR) agonists induce significant adverse effects. Here we introduce a novel RXR partial agonist CBt-PMN (11b), which shows a potent glucose-lowering effect and improvements of insulin secretion and glucose tolerance without the serious adverse effects caused by RXR full agonists. We suggest that RXR partial agonists may be a new class of antitype 2 diabetes drug candidates.
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