Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 4, Issue 1, Pages 75-78Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ml300284b
Keywords
RNA interference; modified siRNAs; molecular modeling; siRNA/PAZ interactions; gene silencing
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- MIUR
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Chemically modified siRNAs were synthesized to enhance the corresponding silencing activities. The introduced modifications endowed siRNAs with high silencing effect, long RNAi persistence, and better serum resistance. Theoretical data allowed us to correlate the observed siRNAs interfering performance with the peculiar interactions with PAZ.
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