Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 2, Issue 8, Pages 608-613Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ml200095w
Keywords
Reactive oxygen species; lipid peroxidation; electron transport chain; mitochondria
Categories
Funding
- Friedreich's Ataxia Research Alliance
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An aza analogue (1) of the experimental neuroprotective drug idebenone has been prepared and evaluated. The compound quenches lipid peroxidation more effectively than a-tocopherol and potently suppresses reactive oxygen species in cells under oxidative stress. It is thought to do so via a catalytic cycle in which both forms of oxidative stress are suppressed simultaneously. Consequently, the compound effectively protects cultured CEM leukemia cells and Friedreich's ataxia fibroblasts from oxidative stress more effectively than idebenone or idebenol.
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