Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 1, Issue 1, Pages 35-38Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ml900021y
Keywords
Antimicrobial PDT; antimicrobial peptides; porphyrin; apidaecin; photosensitizer-peptide conjugate
Categories
Funding
- Italian Minister dell'Istruzione, dell'Universita e della Ricerca
Ask authors/readers for more resources
The conjugation of the cationic antimicrobial peptide, apidaecin Ib, to the anionic photosensitizer, 5(4'-carboxyphenyl)-10,15,20-triphenylporphyrin (cTPP), afforded a new antibacterial agent effective, under light activation, against both Gram-positive and Gram-negative bacteria At low concentrations (15-15 mu M) the conjugate was able to reduce the survival of Escherichia coli cells by 3-4 log(10), and most notably, it resulted photoactive also against hard-to-treat Pseudomonas aeruginosa. although at higher concentration (60 mu M) Under similar conditions, the photosensitizer alone was only photoactive against Staphylococcus aureus while the unconjugated peptide was inactive against all the bacterial strains tested This study shows the possibility of obtaining new broad-spectrum apidaecin photosensitizer conjugates with potent antibacterial activity
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available